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© Image 2015 Vimeo
Drug discovery is difficult and complicated. Using a cutting-edge genomic editing technique called CRISPR, scientists have created a method for testing thousands of drug combinations to help find novel treatments for cancer. They made a library of thousands of combinations of two guideRNAs, each targeting a gene known to be involved in cancer.They used viruses to infect ovarian cancer cells with these guideRNAs, which inactivated the target genes by CRISPR. The researchers discovered some combinations of existing cancer drugs which were a lot more effective at reducing tumour growth than using either drug on its own.

The published paper © 2015 PNAS (doi: pnas.1517883113)

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About the authors

View full profile Max Jamilly from University of Oxford, UK

I'm an entrepreneurial PhD student studying synthetic biology at the University of Oxford. I'm fascinated by all things synbio but especially gene assembly and DNA computing. One of the great things about synbio is how multidisciplinary it is and how quickly the field is evolving. I learn something new every single day! I tweet and blog regularly and am always keen to meet new people interested in synbio.

View full profile Jérôme Lutz from Berlin & Munich, Germany

I like to share the great things I discover daily while researching and working in the field of Synthetic Biology.

When I talk to people about it, they often refer to Science Fiction. However, when I send them links to this wiki and they read through those pages, they start understanding that this is real and it's happening right now.