Drug discovery is difficult and complicated. Using a cutting-edge genomic editing technique called
, scientists have created a method for testing thousands of drug combinations to help find novel treatments for cancer. They made a library of thousands of combinations of two guideRNAs, each targeting a gene known to be involved in cancer.They used viruses to infect ovarian cancer cells with these guideRNAs, which inactivated the target genes by CRISPR. The researchers discovered some combinations of existing cancer drugs which were a lot more effective at reducing tumour growth than using either drug on its own.
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