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Genome Transplantation in Bacteria: Changing One Species to Another

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They completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA. Intact genomic DNA fromMycoplasma mycoides large colony (LC), virtually free of protein, was transplanted into Mycoplasma capricolum cells by polyethylene glycol–mediated transformation. Cells selected for tetracycline resistance, carried by the M. mycoides LC chromosome, contain the complete donor genome and are free of detectable recipient genomic sequences. These cells that result from genome transplantation are phenotypically identical to the M. mycoides LC donor strain as judged by several criteria.

  1. Carole Lartigue
  2. John I. Glass*
  3. Nina Alperovich
  4. Rembert Pieper
  5. Prashanth P. Parmar
  6. Clyde A. Hutchison III,
  7. Hamilton O. Smith
  8. J. Craig Venter
Published Date and JournalScience 3 August 2007: 
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View full profile Jérôme Lutz from Berlin & Munich, Germany

I like to share the great things I discover daily while researching and working in the field of Synthetic Biology.

When I talk to people about it, they often refer to Science Fiction. However, when I send them links to this wiki and they read through those pages, they start understanding that this is real and it's happening right now.