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Health & Medicine

The Health and Medicine Sector is now about to learn the fundamentals of live be truly understanding the genetic code that causes diseases or malfunctions. Also, the constantly falling prices of DNA reading will enable a personalized medicine where a doctor - with the support of big data - will be able to tailor the medical procurement by e.g. predict if a certain drug will cause the desired response.

3D Printing of Tissue 2.0

We are living in an aging society that is facing a decreasing supply of donor organs. To confront this pressing issue, Munichs iGEM Team 2016 developed a game-changing approach to bioprint tissues for biomedical applications. The interdisciplinary work aimed to create a unique ink, named biotINK, to revolutionize bioprinting. The printing process uses a hijacked 3D printer http://2016.igem.org/Team:LMU-TUM_Munich/Hardware and two components of biotINK to induce an instantaneous polymerization re

A CRISPR cure for HIV

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Altering chemotherapy resistance in cancer cells

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Biopharmaceuticals from moss

In collaboration with the University of Freiburg, Germany, Greenovation http://www.greenovation.com/ developed a moss that is able to produce pharmaceuticals. Products stemming from moss have a superior purity, since those cultures neither contain animal-derived components or pathogens that could affect humans, nor antibiotics that may cause resistance.

Cancer drug screening with CRISPR-Cas9

Drug discovery is difficult and complicated. Using a cutting-edge genomic editing technique called CRISPR, scientists have created a method for testing thousands of drug combinations to help find novel treatments for cancer. They made a library of thousands of combinations of two guideRNAs, each targeting a gene known to be involved in cancer.

Dengue Fever erased with suicide mosquitos

With Brazil’s decision in April 2014 to allow the widespread deployment of this transgenic mosquito created by the British start-up Oxitec http://www.oxitec.com/, this mosquito will become the first genetically modified creature to be released into the wild. British start-up Oxitec http://www.oxitec.com/'s transgenic method consists of introducing two new genes into the male A. aegypti: One of them codes for a killer protein and the other for a fluorescent marker that allows researchers to monit

Gene-editing reverses leukaemia in human patient

For the first time, gene editing technology has saved a human life. Doctors in the United Kingdom were able to mass-produce, gene-edited cells to attack the leukaemia into her body and for now, it looks like that the cells fought off her leukaemia.

Living Bones Engineered in the Lab

EpiBone is a revolutionary bone reconstruction company that allows patients to “grow their own bone” from their stem cells.

Lung-on-a-Chip

Combining microfabrication techniques with modern tissue engineering, lung-on-a-chip offers a n ew in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviours of a human lung.

Malaria Medicine Synthesis from yeast

Now there is a modified, biosynthetic process for artemisinic acid, initially designed by Jay Keasling https://en.wikipedia.org/wiki/Jay_Keasling at the University of California, Berkeley https://en.wikipedia.org/wiki/University_of_California,_Berkeley and optimized by Amyris https://en.wikipedia.org/wiki/Amyris_(company). They had engineered yeast to produce small amount of the precursor artemisinic acid. The synthesized artemisinic acid can then be transported out, purified and chemically conv

Moss removing antibiotics from water

The PyscoFilter http://2013.igem.org/Team:TU-Munich removes antibiotics, hormones and various noxious substances from water. It was an iGEM project from the TU Munich in 2013. They have developed a device to implement the filter http://2013.igem.org/Team:TU-Munich/Results/Implementation in an aquatic environment, investigated the application of this new technology and examined its economic feasibility http://2013.igem.org/Team:TU-Munich/Results/Economics. The PhyscoFilter may become a game-chang

Pharmacogenetics predict drug response

Pharmacogenetics is the study of how genes affect a person's response to drugs. This relatively new field allows us to combine pharmacology and genomics to develop effective and safe medication dosages which are specific to an individual's DNA makeup. At present there are over 770,000 injuries http://archive.ahrq.gov/research/findings/factsheets/errors-safety/aderia/ade.html or deaths due to drug reactions per year in the United States. 

Probiotic yoghurt to detect cancer

Liver cancer is one of the most difficult cancers to detect, but synthetic biologist Tal Danino had a thought: What if we could create a pro-biotic, edible bacteria that was "programmed" to find liver tumours? His insight exploits something we're just beginning to understand about bacteria: their power of quorum sensing, or doing something together once they reach critical mass. Using Quorum Sensing and the ability of bacteria to live in tumour cells, Tal Danino developed bacteria that change th

Programmable paper for Ebola detection

Cells are good at sensing what's going on in their environment. Now, this sensing is also possible outside of living cells. Scientists developed a sensor, that notices a specific RNA, e.g. from a virus and than changes colour.

Rapid retrieval of live infectious pathogens

An engineered pathogen-binding protein enables rapid isolation of infectious bacteria from joint fluids and accelerates their identification.

Removing antibiotic resistance from bacteria

WHO estimates that by 2050 the #1 reason people die, will be because of bacterial infections that became resistant to antibiotics and thus can't be treated. We can either find new antibiotics (unlikely), develop completely new forms of medication or we remove the gene that makes bacteria resistant to antibiotics. That's what Eligo Bioscience is building in Paris, based on MIT technology. With € 2 million funding from Seventure http://www.seventure.fr/ they developed a working prototype virus, th

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About the author

View full profile Jérôme Lutz from Berlin & Munich, Germany

I like to share the great things I discover daily while researching and working in the field of Synthetic Biology.

When I talk to people about it, they often refer to Science Fiction. However, when I send them links to this wiki and they read through those pages, they start understanding that this is real and it's happening right now.

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